Can low Tramadol dose be used as an off-label antidepressant?

Tramadol is a common pain management drug. It is an efficient solution to manage moderate to severe pain. However, doctors also recommend to order Tramadol cash on delivery for managing depression. How effective is this drug in treating depression?

Proven off-label solution

According to a recent study in October 2020, 94.6% of the patients who received Tramadol for depression management rated it as an effective solution. However, in cases where a combination of Tramadol with other antidepressants was the primary medication, there were incidences of side effects and withdrawal symptoms. However, in general, a low-dose Tramadol is a right, safe, and fast-acting solution to curb depression.

How Tramadol Dose curbs depression?

The chemical composition of Tramadol is similar to dual-action antidepressants like Venlafaxine. The drug causes an increase in alpha-1 adrenergic receptors in the brain, regulating the dopaminergic receptors, thereby improving the mood. Moreover, it also induces the brain receptors similar to Minanserin or Mirtazapine.

Why is the caution necessary?

The doctors can reduce the Tramadol dose to make it a safer option to reduce depression. The effects of Tramadol on the patients are also positive. However, it is essential to know that caution is vital.

The Tramadol can cause mood-elevation, which is an unwanted side reaction. While the drug induces the receptors, it also stimulates several neurological pathways, which leads to mood elevation. Moreover, it can cause hyperactive delirium in 7% of patients. The effects of hyperactive delirium are emotional liability, confusion, anxiety, and sleep difficulties.
However, such mood elevation and hyperactive delirium are rare in patients with no history of psychiatric disorders.

Effect of Tramadol on other antidepressants

Since Tramadol’s mechanism inside the body is similar to other antidepressants, it is best not to combine them. Even at a very low Tramadol dose, the drug can interact with other antidepressants and cause Serotonin syndrome. Since the other antidepressants and Tramadol both increase serotonin, it would cause serotonin toxicity. Tramadol also reacts negatively with seizure medicines, pain medications, anti-fungal drugs, HIV drugs, and macrolide antibiotics. The common symptoms of drug interactions are breathing problems and severe drowsiness.

Side effects of Tramadol

Beyond these, when you buy Tramadol 100 mg COD, you ought to know the drug’s side effects. The drug’s common side effects are constipation, dizziness, headache, and nausea. The drug’s severe side effects are sleep apnea, hallucination, abdominal pain, loss of appetite, weight loss, and others. If you experience any severe side effects, stop the drug, and talk to your doctor immediately. Common overdose symptoms are very slow breathing, irregular or very slow heart rate, seizure, or coma. Unattended overdose can lead to death in many cases.

Thus, Tramadol is a significant antidepressant for short-term use at a low dosage. However, caution is vital. If you plan to use Tramadol as a solution for depression, talk to your doctor regarding your medical history, medicines you consume (including the over-the-counter drugs like cough medicines), and history of substance abuse. Tramadol is not the ideal solution for all individuals. Let your doctor decide the usefulness and risk of the product for you.